The answer is burning coal! Please forgive me if I get this answer wrong!
DNA ligase is the enzyme that repair irregularities and breaks in the back bone of double stranded DNA. The enzyme function by sealing the repair in the DNA, it seals recombination fragments and it connects okazaki fragments during replication of DNA.
If a mutation reduce the amount of ligase, all the functions of the ligase enzyme listed above will be affected negatively.
What is a pituitary gland
His parents were both heterozygous for hyperthermia and had the recessive gene. (hope this helps)