A presumptive Test presumes the pet presence of the question substance it is useful because it tells the drug is used false positive is possible meaning that the test result is positive but the substance is not present.
not only in the land but also in the ocean there is food web that is why we can find different spices of creature in the ocean alive
there are producer consumer and decomposer
u can present by giving example
u can give oration how the organisms are adapted in the water
Answer:
Fever.
Explanation:
If gram-negative bacteria contain a small amount of Endotoxin in the circulatory system can cause different types of infections such as inflammation, bleeding, hypertension, clotting, and fever.
Endotoxin is known as glycolipids, lipopolysaccharide (LPS) the most potent toxic molecule which is capable of causing lethal shock. It is present in the bacterial cell wall.
The condition is documented as jaundice.
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
