A mutation that involves the permeability of the inner mitochondrial membrane to protons (H+) will affect the amount of ATP. If mutant cells can survive, then they will need more energy to create a suitable gradient.
Cellular respiration is a series of metabolic reactions by which aerobic cells can generate energy in the form of ATP by using the chemical energy stored in the foods.
Cellular respiration can be divided into three sequential stages: glycolysis, the Krebs cycle (also called the acid citric cycle) and oxidative phosphorylation.
During oxidative phosphorylation, the transport of electrons across the inner mitochondrial membrane is coupled to the generation of an electrochemical proton (H+) gradient, which is then used to generate ATP by means of a protein complex known as ATP synthase.
Learn more about oxidative phosphorylation here:
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