Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
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Answer:
incomplete dominance
Explanation:
the offspring is different from the parent
You know this! Let me walk you through! First, define a trophic level.
The best and most correct answer among the choices provided by your question is the first choice or letter A. Margarines are products <span> made up of fatty acids that are derived from alkenes.
</span>The main ingredients in most margarines are vegetable oils like soybean or safflower oil.Vegetable oils<span> are mostly unsaturated, which is a problem because unsaturated oils are liquid at room temperature and cannot be used as spreads.
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