Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Petrochemicals include many things, I would say All of the above. Hope this helped! :)
Answer:
B
Explanation:
location B is more suitable for rock pocket mice
Answer: glycogen is insoluble in water
Explanation:
Glycogen is a better storage of glucose because Glycogen is insoluble in water thus, because of the glycosidic linkages. Storing glucose as glycogen will not upset the osmotic pressure rather than glucose which is soluble in water and if it is stored as glucose it will disturb the osmotic pressure making the solution hypertonic that will cause the cell to lyse.
The glucose from glycogen is readily mobilized and is therefore a good source of energy when needed rather than free floating glucose
