Nitrogen dioxide levels above a certain limit can harm the human respiratory system, increasing a person's sensitivity to and severity of respiratory infections and asthma. Chronic lung disease can be caused by long-term exposure to high levels of nitrogen dioxide.
The lung not being not been able to exchange and remove the carbon dioxide created a health problem due to the concentration of hydrogen ions (H+) being 10X being higher than in normal body. Although the difference is just about 1, it will result increase hydrogen ion concentration 10 times, similarly an increase or decrease in pH from 4 to 2 will give rise to 100 times increase in hydrogen ion concentration. It can equally be applied to hydroxyl in concentration.
Regulated gene expression is crucial to the proper growth & survival of an organism and cannot be over-emphasized. Without it, the genetic code of a chromosome is the equivalent of a computer data file without the appropriate application to run it.