<span>There are numerous proteins in muscle. The main two are thin actin filaments and thick myosin filaments. Thin filaments form a scaffold that thick filaments crawl up. There are many regulatory proteins such as troponin I, troponin C, and tropomyosin. There are also proteins that stabilize the cells and anchor the filaments to other cellular structures. A prime example of this is dystrophin. This protein is thought to stabilize the cell membrane during contraction and prevent it from breaking. Those who lack completely lack dystrophin have a disorder known as Duchene muscular dystrophy. This disease is characterized by muscle wasting begininng in at a young age and usually results in death by the mid 20s. The sarcomere is the repeating unit of skeletal muscle.
Muscle cells contract by interactions of myosin heads on thick filament with actin monomers on thin filament. The myosin heads bind tightly to actin monomers until ATP binds to the myosin. This causes the release of the myosin head, which subsequently swings foward and associates with an actin monomer further up the thin filament. Hydrolysis and of ATP and the release of ADP and a phosphate allows the mysosin head to pull the thick filament up the thin filament. There are roughly 500 myosin heads on each thick filament and when they repeatedly move up the thin filament, the muscle contracts. There are many regulatory proteins of this contraction. For example, troponin I, troponin C, and tropomyosin form a regulatory switch that blocks myosin heads from binding to actin monomers until a nerve impulse stimulates an influx of calcium. This causes the switch to allow the myosin to bind to the actin and allows the muscle to contract. </span><span> </span>
In a human karyotype, autosomes or “body chromosomes” (all of the non–sex chromosomes) are generally organized in approximate order of size from largest (chromosome 1) to smallest (chromosome 22). However, chromosome 21 is actually shorter than chromosome 22.
The nitrogenous bases Adenine form two hydrogen bonds with thymine and the cytosine form three hydrogen bonds with the guanine. Simply, A combines with T and G combines with the C. It is often called as a complementary base pairing because of each base pair bonds only with its specific complementary base partner in a DNA molecule.
