The FDA requires retention of investigational drug study records for The answer is C. At least two years after the investigational drug's approval by the FDA
An investigator shall retain records needed to be preserved under this part for a period of two years following the date a marketing operation is approved for the drug for the explanation for which it is being investigated
Options
A. Yes, because all enzymes and electron carriers are functional
B. No, because with a leaky membrane, the proton gradient cannot be maintained
C. No, because leaky membranes inhibit glycolysis
D. No, because leaky membranes do not allow NADH and FADH2 to donate their electrons to the electron transport chain
Answer:
B. No, because with a leaky membrane, the proton gradient cannot be maintained
Explanation:
The proton motive force (PMF) provides the needed pump to generate electrochemical gradients of proton needed for continue influx into the matix of the mitochondria. The proton Influx generates the energy needed by protein ATPase Synthase for synthesis of ATPs by adding inorganic phosphate to ADP to give ATP.
ADP + Pi -----------→ ATP.
If the mitochondria;l intramembrane leaks, then the PMF can not be sustained, therefore electtrochermical gradient which supplies the energy for ATP synthase for ATP synthesis will not be available. Therefore ATP synthesis stops.
d. the living world. Biologists need to use the living world in order to back up the scientific method.
