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NEWS
What Happens to Tumor Cells After They Are Killed?
Oncology Times: December 25, 2017 - Volume 39 - Issue 24 - p 46-47
doi: 10.1097/01.COT.0000528040.85727.60
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tumor cells: tumor cells
Researchers from Harvard Medical School, Boston, and the Institute for Systems Biology, Seattle, have discovered that the remains of tumor cells killed by chemotherapy or other cancer treatments can actually stimulate tumor growth by inducing an inflammatory reaction. The study also reveals that a family of molecules called resolvins can suppress this unwanted inflammatory response, suggesting new ways to enhance the effectiveness of existing cancer therapies
Conventional, radiation- and drug-based cancer therapies aim to kill as many tumor cells as possible, but the debris left behind by dead and dying cancer cells can stimulate the production of proinflammatory cytokines, signaling molecules that are known to promote tumor growth.
“Dead and dying tumor cells are an underappreciated component of the tumor microenvironment that may promote tumor progression,” explained Charles N. Serhan, PhD, Director of the Center for Experimental Therapeutics and Reperfusion Injury at Brigham and Women's Hospital and Professor at Harvard Medical School. Serhan and colleagues therefore decided to investigate whether tumor cell debris can stimulate tumor growth.
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