You need to understand the main Idea in a story and the details to back it up and just understand it
The answer is C. I think.
The answer is B, the biggest disappointment was isolation from neighbors
When they first meet him, they say "Hail Macbeth, Thane of Glamis, Hail Macbeth Thane of Cawdor, Hail Macbeth who Shalt be King Hereafter." Macbeth, at this time, is already thane of Glamis. However, the other two positions are the predictions. Therefore, they predict Macbeth will become Thane of Cawdor and will later become King.
Hope this helped!! :D