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posledela
2 years ago
15

What did robert hooke first look at with the microscope.

Biology
2 answers:
AURORKA [14]2 years ago
8 0
ANSWER:⇒ cork

People struggled to believe that some of Hooke's images were real because they were so strange and remarkable! Hooke noticed tiny boxlike spaces in cork under his microscope, which he depicted and characterized as cells. Plant cells have been discovered by him!
choli [55]2 years ago
4 0

Answer:

he looked at some tree bark and saw cells

Explanation:

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1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).

2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).

Explanation:

In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.

<u>Normal hemoglobin protein in a RBC</u>

DNA                 CTG ACT CCT GAG GAG AAG TCT

Amino acids     Leu  Thr   Pro   Glu   Glu   Lys   Ser

<u>Sickle cell hemoglobin protein in a RBC</u>

DNA                 CTG ACT CCT <em>GTG</em> GAG AAG TCT

Amino acids     Leu  Thr   Pro   <em>Val</em>   Glu   Lys   Ser

When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.

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