Taxation without representation, the colonists were taxed by the British without the Colonists own government being consulted. Another reason was the that the British did not allow the Colonists to move into the newly aquired area of the northwest region(Ohio, Kentucky etc.), because the British promised the area to the Native Americans. And may I note the Colonists actually considered themselves to be British.
Making the law, review treaties, coin money, approve and deny presidential appointments, trade deals, create a budget, and taxes.
Prejudice. Many people in the south supported slavery, therefore they were prejudiced against blacks. This led to a lack of education, basic rights, health facilities, jobs, etc.