I would say that the answer should be "Helen's challenges with the frustration of learning to communicate".as a blind-deaf person and the excellent analogy with being shrouded in fog and not having how to determine where she was headed but love giving her the light to find her way and eventually get a degree at university.
Using the answer choices provided, D would be the most feasible one in this case.
Indirect object
"me" is affected by the direct object, the comb
The answer is B. Carlos and I went to Chicago for the marathon.