If, while examining a human karyotype, it is observed that there are 22 paired chromosomes and two chromosomes that are not the same size, this would most likely be due to mutation.
<h3>What is mutation?</h3>
Mutation is any change in the nucleotide or chromosomal sequence of a genome.
There are different types of mutation and they include;
- Deletion mutation
- Translocation mutation
- Insertion mutation
According to this question, a human karyotype was observed to have 22 paired chromosomes and two chromosomes that are not the same size.
This observation is likely caused by a mutation that caused the pairing of unequal sized chromosomes.
Learn more about mutation at: brainly.com/question/17106056