The gallbladder contracts when stimulated by cholecystokinin (CCK), pushing bile into the common bile duct. The sphincter of Oddi relaxes at the same time, allowing bile to enter the duodenum.
When stimulated by the hormone cholecystokinin (CCK), the gallbladder contracts, pushing bile through the cystic duct and into the common bile duct. Simultaneously, the sphincter of Oddi relaxes, permitting bile to enter the duodenal lumen.