Question

Tmp/smx has two components that act on different steps in the folic acid biosynthesis pathway and are thus used together. sulfamethoxazole is a structural analog of a compound called paba, competing with it in the enzymatic production of dihydrofolic acid, an intermediate in the synthesis of folic acid. trimethoprim inhibits the step following dihydrofolic acid production and prevents the formation of the biologically active form of folic acid. choose true statements regarding tmp and smx.

Answer 1

Trimethoprim-sulfamethoxazole (TMP-SMX) are a class of antibiotics used in the treatment of bacterial infections due to their inhibitory actions in the folic acid biosynthesis pathway of bacteria.

What is TMP-SMX?

Trimethoprim-sulfamethoxazole (TMP-SMX), otherwise known as co-trimoxazole, is a combination of two antimicrobial agents that work synergistically to inhibit the enzyme systems involved in the bacterial synthesis of tetrahydrofolic acid.

They are used in the treatment of urinary tract infections, respiratory tract infections, cholera, etc.

They can be administered intravenously or orally.

Therefore, Trimethoprim-sulfamethoxazole (TMP-SMX) are antibiotics used in the treatment of bacterial infections.

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