Question

An increase in ATP levels would tend to ____________ the PDH complex. Activate inhibit phosphorylate

Answer 1

An increase in ATP levels would tend to inhibit the PDH.

The oxidation of pyruvate

After the break down of glucose through the metabolic pathway known as glycolysis, the end product, pyruvate, is converted to acetylChoA in the citric acid cycle.

Pyruvate dehydrogenase (PDH) is the first enzyme of the citric acid cycle that is activated by its substrate pyruvate and inhibited by its products acetylChoA together with Adenosine Triphosphate (ATP).

This means that an increase in ATP negatively regulates the enzyme, pyruvate dehydrogenase.

Therefore, an increase in ATP levels would tend to inhibit the PDH.

Learn more about enzymes here:

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