Muscle cramps are caused when the muscle takes longer than normal to relax after a contraction. During contraction, the myosin heads attach on their binding sites on the actin filament and pulls on the filament hence shortening the sarcomeres. For the myosin head to release its binding site on the actin filament, ATP attaches to an active site on the myosin and is hydrolyzed to ADP and Pi. This causes relaxation after a contraction cycle. Cramps, therefore, may be due to depletion of ATP molecule in the muscles cells.
Another reason for cramps may be a high amount of calcium in the muscles that bind to troponin on the actin filaments. This exposes the myosin binding sites longer hence promotes the formation of cross-bridge even when the contraction of the muscle is not intended anymore.
Within the lipophilic (hydrophobic) central region composed largely of fatty acid tails.
Answer:
The correct answer is option A. "A statin".
Explanation:
Statins a type of drug that are prescribed to treat people that are at high risk of developing a cardiovascular disease. Since Joanne is a person with history of coronary artery disease and her LDL levels remained high after trying diet changes, the next step in her treatment will be to take a statin drug. It has been proved that statin are among the most effective drug at lowering LDL levels, therefore, a treatment with a statin will be effective for Joanne's condition.
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