Prader-Willi syndrome (PWS) is a gentic disorder which has an impact on numerous physiological systems. PWS affected individuals (specifically babies) experience delayed growth, significant hypotonia (low muscle tone), and feeding issues. It does effect circadian rhythms in mice models.
SNORD116, often referred to as HBII-85, is a non-coding RNA (ncRNA) molecule that contributes to the alteration of other small nuclear RNAs (snRNAs). Unlike the majority of other snoRNAs, SNORD116 is not significantly complementary to ribosomal RNA and is expressed widely in the brain (but not in PWS patients).
According to the studies, SNORD116 cause sleep defect in patients with Prader-Willi syndrome. Same observation was seen in mouse models too. Paternal expression of SNORD116 is thought to be a potential gene for the sleep disruptions/circadian rhythm’s that the majority of PWS sufferers.
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Answer:
a Anaphase I
b Metaphase I
c Telophase I
d Anaphase II
e Prophase I
f Telophase II
Explanation:
Prophase I begins after the DNA has been duplicated, as shown in picture e. The chromosomes are condensed, and also visible, which is apparent in picture e.
The next stage is called Metaphase I, in which the pairs of homologous chromosomes align at The the centre of the cell and the spindle fibres attach, as shown in picture b.
The pairs of chromosomes are pulled apart to opposite poles of the cell by the spindle fibres., as shown in picture a. This stage is called Anaphase I.
Then, a process called Telophase I occurs, when the cell divides into two daughter cells. One of these cells is shown in picture c.
Picture d shows the stage Anaphase II, where the spindle has attached and the chromatids are pulled to the opposite poles of the cell.
The final picture left is picture f, which shows the daughter cell at the end of meiosis II, where the nuclear envelope is reforming, as in telophase II.
in the microbiology world, is used to determine O Capability of a microbe to perform a specific enzymatic activity. O Staining characteristics. O Nucleic acid-base composition of DNA sequences.
The answer is..<span>The DNA probe binds to the mutated sequence and flags the mutation.</span>