Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
It is the same age as it was when it was swallowed.
Explanation:
Answer:
Doctors believe that diet, medical care, and other lifestyle decisions affect fetal development later in pregnancy. Certain genetic factors can influence things like fetal growth, but this is most shown in the first trimester. Doctors and nutrition experts suggest improving nutritional health several months to a year before planning to become pregnant. Improper nutrition, stress, and overreliance on caffeine, nicotine, or other substances can sometimes impact fertility.
Explanation:
Psychoanalytic type of theorist is most likely to assess people's personalities by having them draw pictures, in the hope that the drawings will reveal underlying personality characteristics.
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What is Psychoanalytic theory?</h3>
Psychoanalytic theory explain human behavior in respect of the interaction of various components of personality.
For example, A 20-year old, healthy and well built, has a irrational fear of mice. The fear makes him shake at the sight of a mouse or rat. He often finds himself in awkward situations because of the fear.
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