Question

__________ of thymocytes is necessary to produce a T-cell repertoire capable of interacting with self-MHC molecules. Select one: a. Positive selection b. Negative selection c. Apoptosis d. Receptor editing e. Isotype switching

Answer 1

Positive selection of thymocytes is necessary to produce a T-cell repertoire capable of interacting with self-MHC molecules. Thus the correct option is A.

What is the purpose of positive selection during T cell development?

To address the necessity that T cells be capable of binding MHC complexes, T cells undergo positive selection. In this process, cells in the thymus present short pieces of proteins known as peptides, on their own MHC class I and class II molecules, allowing immature T cells to bind.

Further the this positive selection process also measures if a T cell will become a CD8+ T cell or a CD4+ T cell. Specifically, if a TCR (T-cell receptor) complex binds strongly to MHC class II, the complex send intracellular signals to induce the expression of a protein called ThPOK. This protein reduces the expression of another key protein, called Runx3, responsible for driving CD8 expression.

For more information regarding MHC complexes, visit:

brainly.com/question/22910247

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