Most enzymes do in fact work on a single substrate in most cases, this is because of the enzyme - substrate specificity. Certain reactant molecules acting as substrates can only fit in the "lock" of particular enzymes and undergo a conformational change and result in Unique products to be released after the reaction has occurred.
Answer:
2. lluvia, sequía, derretimiento de glaciares, aumento de la temporada etc
prophase is the first stage and it looks like all the chromatin condenses into chromosomes and the nucleus dissolves (there is no nucleus when you look at it)