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Oksana_A [137]
2 years ago
12

Apa template about multiple sclerosis

Biology
1 answer:
garik1379 [7]2 years ago
7 0

Answer:

Multiple Sclerosis is an inflammatory disease in which myelin sheath of nerve cells of brain and spinal cord are damaged.

Explanation:

Cause:- (Exact cause of inflammation is not known)

  • But damage is caused due to attack by autoimmune cells or antibodies against myelin sheath.

Types of tissues attack:-

  • Oligodendrocytes and myelin sheath is damaged and stripped away from axon and the process is known as demyelination.
  • Myelin sheaths are made up of fatty tissues and help in transmission of electric impulse.

Result of immune system attack:-

  • Damaged myelin sheath stop forming whIte matter of central nervous system.
  • Hence disrupt coordinating communication between different brain regions.

Signs and symptoms:- vary from person to person

  • Diminished eyesight.
  • Disrupt motor coordination.
  • Weak sensory perception.
  • Fatigue and dizziness.
  • Speech disorder.
  • Muscle weakness and spasticity.
  • Difficulty in urination and stool.

Diagnosis and treatment:-

  • Diagnosis include MRI T2 findings and cerebrospinal fluid specific oligoclonal bands.

#SPJ2

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Do abiotic elements interact with biotic elements in an ecosystem?
myrzilka [38]

Answer:

<em>Yes, the abiotic components interact with the biotic components in an ecosystem.</em>

Explanation:

The abiotic components are the non- living components of an ecosystem. The biotic components are the living components of an ecosystem. Abiotic factors such as sunlight, temperature etc directly affect the biotic components.

For example, the light of the sun is an abiotic component which provides energy to the biotic components, plants, to produce food. Soil is also an abiotic component which provides nutrients and water for the plants which are biotic components.

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3 years ago
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Which elements are the most abundant in living organisms? Select all that apply.
kkurt [141]

Answer:

Carbon, sulfur, hydrogen, oxygen, and nitrogen

Explanation:

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3 years ago
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Identification of key microRNAs and the underlying molecular mechanism in spinal cord ischemia-reperfusion injury in rats
alexdok [17]

The underlying molecular processes for 19 important DE miRNAs in the etiology of SCII were confirmed. The DE miRNAs could serve as potential intervention targets for SCII. Additionally, blocking microRNAs-3568 reduced apoptosis and preserved hind limb function after SCII, possibly via modulating GATA6, GATA4, and RBPJ in SCII.

microRNAs:

  • Short non-coding RNAs called miRNAs (microRNAs) control post-transcriptional gene expression.
  • SCII (spinal cord ischemia-reperfusion damage) is a medical condition that can lead to paralysis and paraplegia, among other serious effects. The development of SCII is influenced by aberrant microRNAs expression. Different microRNAs expression results could be caused by variations in the experimenters, filtering circumstances, control choice, and sequencing platform.
  • The purpose of this study is to investigate the important differently expressed microRNAs (DE miRNAs) and the underlying molecular mechanism in SCII by methodically analyzing the available SCII microRNAs expression data. A thorough bioinformatics study of 23 representative rat SCII miRNA datasets from PubMed was carried out. On mi RDB, the target genes of important DE miRNAs were predicted.
  • Functional enrichment and transcription factor binding analyses using the DAVID and T Fact S databases. Nine were increased (miR-144-3p, miR-3568, miR-204, miR-30c, miR-34c-3p, miR-155-3p, miR-200b, miR-463, and miR-760-5p) and ten were downregulated (this study found 19 important DE miRNAs involved in SCII) (miR-28-5p, miR-21-5p, miR-702-3p, miR-291a-3p, miR-199a-3p, miR-352, miR-743b-3p, miR-125b-2-3p, miR-129-1-3p, and miR-136).Target genes of the increased DE miRNAs underwent KEGG enrichment analysis, which identified the pathways primarily involved as being the cGMP-PKG and cAMP signaling pathways. According to KEGG enrichment analysis of the downregulated DE miRNAs' target genes, the main signaling pathways involved were the Chemokine and MAPK signaling pathways. The target genes of the increased DE miRNAs were clearly enriched in biological processes such brain development and the positive control of transcription from RNA polymerase II promoter, according to GO enrichment analysis.
  • The majority of the target genes of the downregulated DE miRNAs were enriched in biological processes such intracellular signal transmission and the inhibition of cell growth. The transcription factor study revealed that the four transcription factors, SP1, GLI1, GLI2, and FOXO3, had significant regulatory effects on the main DE miRNAs' target genes. MiR-3568 stood out among the elevated DE miRNAs as being particularly intriguing. SCII results in significant neurological deficiencies in the lower extremities, but miR-3568 anti-miRNA oligonucleotides (AMOs) enhance neurological performance. When compared to the sham group, cleaved caspase-3 and Bax were significantly elevated in SCII, however the overexpression was inhibited by miR-3568 AMO. In contrast to cleaved caspase-3, Bcl-2 expression levels exhibited a pattern. Following the attenuation of this increase by SCII and microRNAs-3568 AMO, the expression of GATA6, GATA4, and RBPJ reduced.

Learn more about microRNAs here brainly.com/question/14979443

#SPJ4

8 0
2 years ago
The nurse is caring for a 10-year-old child who weighs 82.2 lb (37.3 kg) and is to receive 2.5 ml/kg/hr of 0.45% nacl solution.
Vitek1552 [10]

Answer:

The correct answer would be 93 milliliters.

The same can be explained with the help of the unitary method.

The volume of solution required for 1 kg of weight in one hour = 2.5 milliliters (given in the question).

Thus, the volume of the solution required for 37.3 kg of weight in one hour = 2.5\times37.3 milliliters

It comes out be 93.25 milliliters.

Thus, around 93 milliliters of the solution should be given to the child of weight 37.3 kg in one hour.

6 0
3 years ago
The uterus has a thick, muscular wall. What function does this feature most likely support? A. It can contract to push eggs thro
cluponka [151]

Answer:

The correct option is B.  It helps the fertilized egg attach to the uterine wall.

Explanation:

The uterus contains some of the strongest muscles of the body. It is made up of three thick layers:

1. The perimetrium 2. the myometrium and 3. the endometrium.

The walls of the endometrium thicken during ovulation and also pregnancy.

When fertilization occurs, the walls of the uterus help the eggs to stick to the uterine walls. The endometrium thickens more and more to protect the egg and to nourish it..

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