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a certification verifies that a professional has met a certain set of criteria for a skill or job as measured by a third-party assessment. A license is verification by a government agency that a professional is able to perform a particular occupation in a particular location, such as a certain stat
Explanation:
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Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications.
Keywords: Absorption, adverse drug reaction, distribution, drug-drug interactions, excretion, metabolism, poly-therapy
I'm not sure that this is 400 words but this is what I came up with.
Answer:
The best answer to your question: Which type of neuroglia would play a role in controlling glutamate levels in the chemical environment, would be: Astrocytes.
Explanation:
From among the neuroglia, or support cells in the brain, whose purpose is to aid neurons in their different functions, astrocytes are not just one of the most numerous, but also one of the most vital for neuronal support. Amongst one of their most central functions is to help in the control of neurotransmitter emition and retention in the synaptic cleft, between two communicating neurons, and therefore, helps regulate the responses from post-synaptic, and pre-synaptic neurons. It is also responsible for clearing up the presence of ions in the extracellular space, and producing ATP, which regulates the amount of neurotransmitters that are released, and taken, by pre-synaptic, and post-synaptic neurons.
In ALS (Amyotrophic Lateral Sclerosis) the issue with glutamate, a neurotransmitter that excites post-synaptic neurons into releasing excess amounts of calcium, is that this hyper-excitatory response leads neurons, particularly motor neurons, to die, and this is what causes ALS. It has been found through research that astrocytes have to do in this process, but it is not clear yet whether there is a failure in their control system, as ALS is still a condition that is very much under study and still without a cure.