Answer:
the pathway will be under-expressed.
- the alpha subunit helps to bind with either GDP or GTP. when the α subunit is bound with GDP, it will be bound to β and γ subunits and thus forms an inactive state for G-protein.
- when the alpha subunit binds with the GTP, it becomes activated and dissociates β and γ subunits.
if G-protein Coupled Receptor is unable from dissociating β and γ subunits, then the pathway will go under expression.
The chemical qualities of the alpha subunit allow it to bind easily to one of two guanine subunits, GDP or GTP. The protein thus has two functional formations. When GDP is bound to the alpha subunit, the alpha subunit remains bound to the beta-gamma subunit to form an inactive trimeric protein.
G-proteins, cAMP, and Ion Channel Opening. The alpha subunit activates adenylate cyclase, in purple, and loses GTP. Adenylate cyclase converts ATP to cyclic AMP, which then activates Protein Kinase, shown in blue. Protein Kinase phosphorylates an ion channel, letting sodium ions rush into the cell.
As a result of the ligand binding to its site on the G-protein-linked receptor, A) the G-protein changes conformation and GTP replaces the GDP on the alpha subunit. ... Inactivation of the alpha subunit occurs when its own phosphorylase activity removes a phosphate from the GTP.
Answer:
1. Claws 2. Hibernation 3. Venom
Explanation:
Answer: the tundra is important to protect is that it serves as a habitat for migratory populations, like waterfowl, shorebirds, caribou and several bear species. It is home to endangered animals such as the Arctic Fox, Polar Bear, Grizzly Bear, Caribou, and Musk Ox.
Explanation:
Answer:
List three ways of reducing friction. 1.Polishing the rough surface. 2.Providing all bearings or wheels between the moving parts of a machine or vehicles reduce friction and 3.allow smooth movement as rolling friction is less than sliding friction.
