The correct statements are:
•An NLS can be a monopartite or bipartite signal which includes a significant number of basic amino acids.
• The recycling of importins back to their original conformation requires GTP hydrolysis in the cytoplasm.
The other answers are incorrect because GTP is not required for an importin to bind to an NLS but for the release of importin and an NES or nuclear export signal is the sequence in a protein for export from the cell nucleus to the cytoplasm, not to the nucleolus.
A) That organisms have changed over time
