An increase in alcohol consumption
Alcohol can boost GABA activity in the brain in one of two ways: either by acting on the presynaptic cell, which increases GABA release, or. It can influence the postsynaptic (i.e., signal-receiving) neuron, promoting the GABAA receptor's activation.
The brain circuits that regulate motivational processes, such as arousal, reward, and stress, are altered by chronic alcohol consumption. These modifications impact systems that use dopamine, opioid peptides, -aminobutyric acid, glutamate, and serotonin as signaling molecules as well as systems that control the brain's stress response. Frequent episodes of intoxication, obsession with alcohol, use of alcohol in spite of negative effects, and a need to seek out and use alcohol are all signs of alcoholism developing.
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