Studies using single cells have identified the transcriptome signature of many kidney cell types. Acute kidney injury (AKI) impacts cells differently and is regionally distributed in space.
Why integration of spatial and single-cell transcriptomics localizes epithelial cell-immune cross-talk in kidney injury?
Acute kidney damage (AKI) is a fatal condition that raises morbidity and death rates. A deeper understanding of the molecular etiology of AKI is necessary to identify therapeutic targets for treatment. Epithelial, endothelial, fibroblast, vascular smooth muscle, resident immunological, and invading immune cells are only a few of the various cell types that make up the renal milieu and interact with one another within a universe of distinct microenvironments.
Additionally, different types of kidney cells are impacted differently by AKI. By identifying the transcriptome fingerprints of certain cells within the kidney, single-cell and single-nuclear sequencing have recently demonstrated significant advances in the development of a molecular atlas of the kidney. To understand the interaction between cells and structures in particular renal microenvironments, spatial anchoring is crucial.
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