Question

How does the fact that telomeres are long stretches of repeated nucleotides lessen the impact that somatic cells don’t have telomerase?

Answer 1

Telomerase activity is controlled during development and is extremely low in somatic (body) cells, virtually undetectable. These somatic cells age because they do not frequently use telomerase.

• Telomeres are repetitive sections at the very ends of chromosomes that are present in a variety of eukaryotic species, including humans and unicellular protists.
• Each round of DNA replication wears down a little portion of the telomeres, which serve as caps to safeguard the interior chromosomal regions.
• Most somatic (body) cells do not typically have telomerase activity, but certain adult stem cells and germ cells—the cells that produce sperm and eggs—have.
• Adult germ cells, tumor cells, and fetal tissues all contain telomerase. Telomerase activity is controlled during development and is extremely low in somatic (body) cells, virtually undetectable. These somatic cells age because they do not frequently use telomerase.

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