Question

Chemotherapy in adult highgrade glioma: a systematic review and metaanalysis of individual patient data from 12 randomized trials

Answer 1

Systemic chemotherapy's impact on survival and recurrence in people with high-grade glioma has not been conclusively studied.

What is Systemic chemotherapy?

Patients undergoing systemic chemotherapy can get their chemotherapy drugs intravenously or orally. The medication may be injected into the body intravenously, or through an IV, or intramuscular, into a muscle (IM).

Some Key features of systemic chemotherapy are-

• Background: In order to evaluate the effects of such treatment on survival and recurrence, we conducted a systematic review and meta-analysis.
• Methods: From 12 randomised controlled studies, information on 3004 patients was incorporated (11 published and one unpublished).
• Findings: Overall, the findings indicated a significant survival extension associated with chemotherapy, with a hazard ratio of 0.85 (95 percent confidence interval [CI] 0.78–0.91, p0.0001) or a relative reduction in mortality risk of 15%. There was no proof that a patient's age, gender, histology, performance status, or degree of resection affected how chemotherapy worked in any particular way.
• Interpretation: Further research into pharmacological treatment for malignant tumors is encouraged by this modest but noticeable improvement in survival from chemotherapy.

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