Explain how the pKa for histidine 57 is important to its role in the mechanism of chymotrypsin action.

Biology

1 answer:

oksano4ka [1.4K]2 years ago

6 0

During the chymotrypsin reaction, both the protonated and unprotonated forms of histidine 57 occur.
This is possible within the physiological pH range thanks to its pKa of 6.0.

<h3>Describe the role that histidine 57 plays in the chymotrypsin mechanism.</h3>

General base catalysis and general acid catalysis are two of the processes that histidine accomplishes.
As a general base, it takes a hydrogen from serine 195 in the first step.
The amide group of the peptide bond that is breaking is given hydrogen in the next phase, which is an acid catalysis step.
The second stage of the reaction is conducted according to a similar plan.

<h3>Role of nucleophilic catalysis in the chymotrypsin reaction mechanism:</h3>

The nucleophile that attacks the substrate peptide bond in the first phase of the reaction is serine hydroxyl.
Water is the nucleophile that attacks the intermediate acyl-enzyme in the second step.

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