Question

The measurement of rubella IgG antibody avidity can be used to distinguish between recent and remote rubella infection. Antibody avidity (the overall strength of binding between the antigen and antibody) increases with time; this is known as maturation of the immune response. As the immune response matures, low avidity antibodies are replaced with high avidity antibodies. These avidity differences can be detected by using protein denaturants such as diethylamine (DEA) in the washing step of an enzyme-linked immunoassay (EIA) for rubella IgG. In acute rubella virus infections, specific, low-avidity IgG lasts for up to three months after appearance of the IgG response. The presence of high avidity antibodies, which develop by about three months after infection, provides evidence of remote infection. The cut-off between low and high avidities has to be established by using standardized sera and a particular EIA kit.

Answer 1

Antibody avidity (the overall strength of binding between the antigen and antibody) increases with time; this is known as maturation of the immune response.

What is Rubella virus ?

The red rash of rubella, a common viral illness, is what makes it most recognizable. German measles and three-day measles are other names for it. Most people may only have minor symptoms from this virus. However, it can have catastrophic consequences for unborn children when mothers contract the infection while pregnant.

What is antibody avidity ?

The intensity with which an antibody attaches to a challenging antigen is known as antibody avidity. For evaluating relative antibody avidity to various antigen types, many techniques have been reported.

Following pneumococcal conjugate vaccination, babies develop antibodies with increasing avidity that rises from postprimary samples to prebooster samples and continues to rise over time.

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