Question

The nurse is caring for a client receiving mannitol via intravenous (IV) infusion. A vial is sent from the pharmacy, and in preparing the medication the nurse notes that the vial contains crystals. What is the most appropriate nursing action

Answer 1

Appropriate nursing action would be place the vial in warmer water.

When exposed to low temperatures, solutions of mannitol may crystallize. If crystals are observed, the container should be warmed to redissolve, then cooled to body temperature before administering. Diluted solutions of mannitol are less likely to crystallize, especially if the final concentration is less than 15%.

An administration set with a filter should be used for infusions containing 20% or more of mannitol. At concentrations of 15% or greater, mannitol may crystallize at low temperatures. Mannitol should only be given intravenously and never given intramuscularly or subcutaneously. Mannitol should not be administered with whole blood.

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