Question

Improved bone regeneration through amniotic membrane loaded with buccal fat pad-derived MSCs as an adjuvant in maxillomandibular reconstruction

Answer 1

Mesenchymal stem cells and HAM together may improve bone repair, especially in the horizontal dimension. Additionally, this technology lessens secondary bone resorption and the quantity of collected autogenous bone.

HAM:

• Background: Human amniotic membranes (HAMs), a biological membrane with potential for cell therapy, osteogenesis, and healing, have come under the spotlight as a way to improve the results of treating bone abnormalities. The goal of the current study is to clinically evaluate the possibility of HAM loaded with stem cells from the buccal fat pad (BFSCs) as an osteogenic covering for only bone transplants to maxillomandibular bone lesions.
• Materials and methods: The current investigation included nine patients with jaw bone abnormalities. Iliac crest bone graft with HAM covering (n = 5) and iliac bone grafts coated with HAM loaded with BFSCs (n = 4) were the two study groups that the patients were divided into. Cone beam computed tomography was carried out for radio morphometric characterization five months after the grafting and before the installation of the implant.
• Results: The mean increase in bone width was found to be significantly greater in the HAM + BFSCs group ($4.42$ ± $1.03$ mm versus$3.07$ ± $0.73$ mm, p < $0.05$). Further, the changes in vertical dimension were greater in the HAM + BFSCs group ($4.66$ ± $1.06$mm versus $4.14$ ± $1.03$ mm, p > $0.05$).

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