Question

senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.

Answer 1

Senescence-like phenotype is normally regarded as a suppressive manner, both by preventing cancer cellular proliferation and suppressing malignant development from pre-malignant to malignant disorder.

Senescence is generally regarded as a tumour suppressive method, both with the aid of preventing cancer cell proliferation and suppressing malignant progression from pre-malignant to malignant disease. Cell senescence limits the replicative potential of cells, as a consequence stopping the proliferation of cells which are at distinct stages of malignancy.

A recent frame of evidence shows that induction of senescence can be exploited as a foundation for most cancers therapy. Senescence is a double-edged sword which could function in contrary directions. It far a capacity mechanism for a cell to avoid malignant transformation. however, senescence can also sell most cancers improvement with the aid of changing the cellular microenvironment thru a senescence-related secretory phenotype.

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