Senescence-like phenotype is normally regarded as a suppressive manner, both by preventing cancer cellular proliferation and suppressing malignant development from pre-malignant to malignant disorder.
Senescence is generally regarded as a tumour suppressive method, both with the aid of preventing cancer cell proliferation and suppressing malignant progression from pre-malignant to malignant disease. Cell senescence limits the replicative potential of cells, as a consequence stopping the proliferation of cells which are at distinct stages of malignancy.
A recent frame of evidence shows that induction of senescence can be exploited as a foundation for most cancers therapy. Senescence is a double-edged sword which could function in contrary directions. It far a capacity mechanism for a cell to avoid malignant transformation. however, senescence can also sell most cancers improvement with the aid of changing the cellular microenvironment thru a senescence-related secretory phenotype.
