Question

Cholecystokinin, which is produced in the small intestine, inhibits gastric secretions in the stomach. True or false?.

Answer 1

The small intestine produces cholecystokinin, which stops the stomach from secreting gastric juices. The statement that follows is true.

Discussion about Cholecystokinin-

• A peptide transmitter called cholecystokinin(CCK) is released into the blood after a meal and is largely made by enteroendocrine cells in the proximal small intestine. Circulating CCK stimulates pancreatic secretion and gallbladder contraction, controls stomach emptying and bowel movement, and promotes satiety via binding to particular cholecystokinin-1(CCK-1) receptors mostly on pancreas, stomach smooth muscle, and peripheral nerves.
• The coordination of nutritional intake, digestion, and absorption is achieved via these effects. The main dietary components that increase cholecystokinin(CCK )release are ingested fat and protein.
• CCK was first discovered to be a 33-amino-acid polypeptide. Yet, bigger and smaller versions of CCK were found in the brain, gut, and blood from its very discovery. A preprohormone undergoes posttranslational synthesis to yield all variants of CCK from a particular gene.

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