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lutik1710 [3]
2 years ago
7

Antioxidant therapy for pain reduction in patients with chronic pancreatitis: a systematic review and meta-analysis.

Medicine
1 answer:
tankabanditka [31]2 years ago
3 0

Antioxidant therapy for pain reduction in patients with chronic pancreatitis: a systematic review and meta-analysis.

<h3>Objectives:</h3>
  • Oxidative stress is strongly implicated in the pathogenesis of chronic pancreatitis (CP); however, clinical studies evaluating antioxidant therapy (AOT) in the management of CP pain have yielded conflicting results.
  • The aim of this meta-analysis was to evaluate the efficacy of AOT in pain reduction in CP patients.
<h3>Methods: </h3>
  • From the beginning until December 2013, two writers separately performed a thorough literature search.
  • The Mantel-Haenszel and DerSimonian-Laird techniques were used to compute the relative risk (RR) and 95% confidence intervals (CIs).
<h3>Results: </h3>
  • There were eight studies totaling 446 patients (234 in the AOT group and 212 in the control group).
  • Overall, compared to the control group, CP patients who received AOT saw a substantial decrease in pain (RR, 0.73; 95% CI, 0.58-0.91; P = 0.006).
  • Trials with primarily alcoholic CP patients (RR, 0.60; 95% CI, 0.47-0.77; P 0.0001) and studies with patients who were on average     42 years old or older (RR, 0.66; 95% CI, 0.49-0.89; P = 0.006) also shown a substantial advantage of AOT over placebo in the subgroup analysis.
<h3>Conclusions: </h3>
  • This is the first meta-analysis to compile all the evidence that is currently available and demonstrate the value of AOT in reducing pain in CP patients.
  • To better identify the patient and illness characteristics favoring response, the ideal formulation, and the duration of AOT, larger studies with longer follow-up are urgently needed.

To learn more about antioxidants visit:

brainly.com/question/15365788

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After a signal binds to a signal receptor, the next step is transduction. Why is the signal transduction step necessary?.
mr_godi [17]

Cells respond to environmental effects through signal transduction, which promotes healthy cell growth and normal cell function.

<h3>Why is the signal transduction step necessary?</h3>

The reason why after a signal binds to a signal receptor, we need the next step is as follows:

  • For the purpose of triggering an appropriate cellular response, living creatures have evolved a vast range of intricate procedures to send signals from the outside to the inside.
  • These molecular pathways can develop flaws that result in a variety of ailments, including diabetes, cancer, and psychotic conditions.
  • It is the mechanism by which a cell responds to the stimuli it receives from the environment by diffusion of those signals to its internal compartments.
  • Signal transduction is the process by which a cell translates a given signal or external stimulus into another signal or specific response.
  • First, a particular receptor on the cell's membrane or cytoplasm must be activated by a signaling molecule (also known as a ligand). transduction.
  • Ligand-receptor binding is extremely specific; it can be compared to a lock and key.
  • Second messengers are chemicals that enable intracellular signal amplification after a signal has been received.
  • A ligand's interaction to a receptor may result in the production of hundreds of second messenger molecules, which may then change thousands of effector molecules to cause a variety of reactions.
  • Signal transduction enables cells to perceive, interpret, and react to various environmental signals, enabling them to carry out their usual functions.

To learn more about signal transduction visit:

brainly.com/question/13989766

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Which of these best describes the purpose for “hands-only” CPR?
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Which clinical signs are associated with periodontitis?
Serhud [2]

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This disease can cause loosening of teeth. But it is commonly preventable. It is because of poor hygiene of mouth. It results in bleeding of gums. It also results in decrease in depth of sulcus to 4mm.

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