Question

The rabies virus is 12 kb in length. Based on the coating ratio of nucleoprotein (n), what would be the total number of nucleoprotein (n) molecules enclosed in a single virion?

Answer 1

Rabies virus nucleoprotein encapsidates the genomic and antigenomic RNA of RV to form the viral ribonucleoprotein complesx. Rabies virus is nonsegmented negative strand RNA virus within the Rhabdoviridae family.

It is zoonotic , aftal and progressive neurological infection caused by rabies virus of genus lyssavirus and family rhabdoviridae.Its genome is 12 kb in length and encodes 5 monocistronic mRNAs encoding the nucleocapsid  protein, matrix, phosphoprotein, the trans-membrane, glycoprotein and viral RNA depent RNA polymerase.

Rabies virus vaccine vector tolerate large , multiple foreign genes , upt to 6.5 kb and live rabies virus vector with very low pathogenic potential can be constructed. It contains foreign glycoproteins such as hepatitis E2 or HIV .

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