Question

A hot water tail-flick test measures the time it takes rats to remove their tail when it is dipped in hot water. Rats housed with a running wheel exhibit a delayed response in the test. Based on this response, which type of sensory receptors are most likely negatively regulated by exercise

Answer 1

Nociceptors, which are pain receptors activated by hot water, are adversely regulated if there is a delayed response.

What is Nociceptors?

Nociceptors are sensory receptors that detect signals from damaged tissue or the danger of injury, as well as substances generated by the damaged tissue. Nociceptors are free (bare) nerve terminals present in the skin, muscle, joints, bone, and viscera. It was recently discovered that nerve terminals include transient receptor potential (TRP) channels that feel and detect injury. TRP channels, which have six transmembrane domains and a pore between domains 5 and 6, are analogous to voltage-gated potassium channels or nucleotide-gated channels. They convert painful inputs into receptor potentials, which then activate action potentials in pain nerve fibers.

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