For the transport of metals across the fluids and the body membranes, the intracellular potential is needed. But sometimes due to the toxicity of lead, the process is affected especially in the digestive tract.

How bioaccessibility of lead is affected in the human digestive tract?

Both the organic (tetra alkyl lead) and inorganic forms of lead have been demonstrated to be extremely hazardous in experimental studies. This lead absorption, which typically occurs by inhalation or food contamination, is influenced by variables including absorption rate, particle size, and solubility. The majority of the lead that is inhaled is in tissues that contain minerals. Following speciation, Lead's binding power increases in comparison to Zinc and Calcium, which has an impact on fluidity. Lead's bioavailability seems to be reduced when food is present. The concentration of lead may also be reduced by pyromorphite. Since solid state speciation happens when the pH is between 6 and 7, Now, this results in a change in circumstances from the stomach to the intestinal tract, leading lead to transform into lead phosphate, which is less soluble and reduces bioaccessibility.

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