The mechanism of somatic recombination known as V(D)J recombination only takes place in developing lymphocytes at the beginning of T and B cell maturation. As a result, B cells and T cells, respectively, have a very varied repertoire of antibodies/immunoglobulins and T cell receptors (TCRs).
<h3>What are immunoglobulin genes ?</h3>
Only B cells can make immunoglobulins, which are encoded by the immunoglobulin genes. The two identical heavy chains that make up immunoglobulin molecules are coupled with the two identical light chains, kappa and lambda. There are numerous chromosomal locations where the immunoglobulin genes are found.
- B-cell immunoglobulin gene rearrangement tests are used to help diagnose non-Hodgkin B-cell lymphomas and evaluate for residual or recurrent disease after treatment. There are many different types of B-cell lymphoma and each has different characteristics, prognoses, and a likely response to therapy
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