Question

enkephalin-induced depression of single neurons in brain areas with opiate receptors—antagonism by naloxone

Answer 1

Induced depression of single neurons in brain areas with opiate receptors

• Enkephalin, applied microiontophoretically, depressed spontaneous and glutamate-induced firing of  one neuron in frontal cortex, caudate nucleus, and periaqueductal gray matter, where enkephalin and high concentrations of opiate receptors are met.
• More than one depressions were blocked by the specific narcotic antagonist naloxone. The results  are durable with a neurotransmitter or neuromodulator role for this new brain pentapeptide.
• Opium derivatives have been in medical use for the last  2000 years, and may be   longer than any other class of drugs
• . The brain regions which was  involved in these actions have been identified in some instances by local microinjection of pmole quantities of opioids.

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