Question

a patient with xeroderma pigmentosum is prone to developing multiple skin cancers starting in childhood. this occurs because of a mutation in a gene that codes for enzymes that help repair dna damage through the nucleotide excision repair (ner) pathways. how does ner differ from other repair mechanisms? in ner:

Answer 1

Mammals primarily use Nucleotide Excision Repair (NER) to erase large DNA lesions like those caused by UV radiation. Light, the environment, and several DNA-based cancer chemotherapeutic drug users.

NER deficiencies linked to the genetic condition Xeroderma pigmentosum, which is incredibly risky for developing skin cancer. The fundamental distinction between base excision repair and nucleotide excision repair is that base excision repair only corrects damaged bases, which are non-bulky lesions, whereas nucleotide excision repair corrects bulky DNA adducts by removing short single-stranded DNA segments. Damage recognition, subunit assembly, dual incisions that result in excision of the damage-containing oligomer, resynthesis to fill in the gap and ligation to regenerate an intact molecule are the basic mechanisms of nucleotide excision repair.

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