The mono- clonal antibody that forms Herceptin was isolated by inoculating mice with cells expressing excess levels of human HER2 protein, followed by immunization of the murine antibody.
A DNA probe from the human HER2 gene was then used to discover HER2 gene amplification in human breast cancer. The process is known as recombinant DNA technique .
HER2 plays an important role in the signaling network that drives cell proliferation. Herceptin is believed to block intracellular signaling pathways. By attenuating the signal transduction downstream, Herceptin may promote apoptosis and arrest cell proliferation. Herceptin is the brand name of a medicine called trastuzumab. some common uses of Herceptin are they are used in treatment of breast cancer, esophageal cancer and stomach cancer.
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