Researchers also measured oxygen consumption and intracellular NADH levels in BP-CML cells after exposure to pyrivinium. They most likely observed an increase in NADH levels and a decrease in O2 consumption.
Pyrivinium is an anti-helminthic drug effective against pinworms. The salts of pyrvinium can also be utilized as anticancer agents.
The findings of the study greatly favor a mechanism of pyrivinium which includes inhibition of mitochondrial respiration (MR). Since MR consumes oxygen, therefore, pyrivinium should reduce oxygen consumption.
NADH provides electrons to the electron transport chain (ETC). However, if the ETC is not operating properly, the NADH formed by the citric acid cycle would not be oxidized to NAD+ and H+. Therefore, NADH levels would increase ultimately.
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