Hemoglobin is 6.0% heme (C₃₄H₃₂FeN₄O₄)
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mol of heme]
The protein haemoglobin, which is required to bind oxygen in the bloodstream, is a precursor to heme. Both the liver and bone marrow can biosynthesize heme.
Heme is a coordination complex that "consists of an iron ion coupled to porphyrin serving as a tetradentate ligand, and to one or two axial ligands," according to biological terminology. The term is ill-defined, and many illustrations leave out the axial ligands.
Heme is one of the most often utilised metalloporphyrins employed by metalloproteins as prosthetic groups, and it defines the family of proteins known as hemoproteins.
The biologically significant hemoproteins heme peroxidase, myoglobin, cytochromes, catalases, and endothelial nitric oxide synthase all contain heme, which is most generally known as a component of haemoglobin, the red colour in blood.
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