Under normal conditions, some interstitial fluids slowly escape through the epidermis via a process called epidermis/trans-epidermal water loss.
Interstitial fluids are the fluids filled between the spaces present around the cells. This fluid is present due to the leakage of substances from the blood capillaries. It also aids in transport of oxygen, nutrients and removal of waste product from the cell.
Epidermis/trans-epidermal water loss is the passive evaporation of water from the skin. This is the reason why skin sometimes may feel very dry after a person wakes up. This evaporation happens de to the presence of water vapor gradient across both sides of the skin.
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