A patient is taking the nonsteroidal anti-inflammatory drug indomethacin (Indocin) as treatment for pericarditis. The nurse will teach the patient to watch for Nausea and vomiting.
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What is pericarditis?</h3>
- An enlargement and irritation of the heart's delicate, sac-like membrane (pericardium).
- A viral infection or cardiac stroke are two possible causes of pericarditis.
- The cause is frequently unknown.
- Sharp, stabbing chest discomfort that may radiate to the left shoulder and neck is the most typical symptom.
- Pericarditis typically starts suddenly and ends quickly.
- Most cases are minor and resolve on their own most of the time.
- Medication and, in rare situations, surgery may be used as treatments for more serious conditions.
- Viral infections are frequently the cause of pericarditis, while the exact origin is frequently unknown.
- Following an infection of the digestive or respiratory systems, pericarditis can develop.
- Autoimmune diseases like lupus, scleroderma, and rheumatoid arthritis can lead to chronic and recurrent pericarditis.
Learn more about pericarditis here:
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Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
Then you should go to the pool party
Explanation:
YOLOOOO YOU ONLY LIVE ONCE MAKE MISTAKES GO BE HAPPY :)
They lacked the proper equipment so sensitive chemical tests and analytical instruments. Hope this helps!