The receptors for steroid hormones are reside inside the cell instead of the membrane surface, like most other signal receptors. So, Steroid hormones are lipid soluble. Steroids gain access to their receptors because they can readily diffuse through the lipid bilayer of the cell membrane.
Steroids are man-made hormones which are lipid soluble and are normally produced by our adrenal glands, which are two small glands always found above the kidneys. When steroids are taken in higher doses than the amount your body normally produces and that steroids reduce redness and swelling.
Therefore, steroid harmone signalling is a lipid-soluble signalling which can be transmit through the bloodstream from an endocrine gland bound by a steroid binding protein (SBP).
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