The answer is Aspiration pneumonia. The low pressure in the cuff of the endotracheal tube is a risk for the aspiration pneumonia while the high cuff pressure can cause ischemia, pressure necrosis and tracheal bleeding.Hope this would be of big help.
The process of protein synthesis is known as translation. During this process, the mRNA is being copied into an orderly sequence of amino acids to produce a polypeptide.
During gene transcription, a fragment of DNA called gene is used as a template to generate a complementary messenger RNA (mRNA) sequence.
Afterward, this mRNA will be used as a template to create a protein by a process called translation.
The linear order of triplets of nucleotides or codons in mRNA will be used to add ordered amino acids to the growing polypeptide chain (i.e., the protein).
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A murine model of hemorrhagic refractory shock showed improved post-resuscitation survival time with adjuvant cytosolic energy replenishment.
<h3>
Objective:</h3>
- Resuscitation of a patient with refractory hemorrhagic hypovolemic shock (HS) is difficult.
- HS is linked to severe reductions of cellular energy nucleotides, which can result in cardio-circulatory arrest and mortality.
- Vasopressors, most often norepinephrine, are typically briefly supplied to control a persistent hypotension that is not rectified by intensive resuscitation attempts in order to avert an impending cardio-circulatory arrest.
<h3>Method</h3>
The following five groups of 10 each were randomly assigned to 50 male Sprague-Dawley rats:
- HS/conventional resuscitation (CR), HS/CR+norepinephrine, HS/CR+vasopressin, HS/CR+vesicles, and HS/CR+ATPv.
- ATPv, which are highly fusogenic lipid vesicles encasing ATP, were used to directly replace the cytosol with ATP.
- Direct cytosolic ATP delivery is made possible by the instantaneous fusion of the ATPv with the cell membrane.
- The study's endpoint was established as the post-resuscitation survival period.
<h3>Results:</h3>
The SI and MAP showed that all animals experienced the same kind of shock. According to the long-rank Mantel-Cox test and Kaplan-Meier survival curves, the median post resuscitation survival periods were as follows: HS/CR+Nor epinephrine = 35.5 min; HS/CR+Vasopressin = 20 min; HS/CR+Lipid Vesicles control = 88.5 min; and HS/CR+ATPv = 158.5 min
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32 Fahrenheit equals to 0 C, so we can say that it's cold
